It was prescribed to me by my neurologist after he had evaluated me extensively for various autoimmune-related issues.
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Modafinil has several positive effects for me: About 30 minutes after I take it, I feel a renewed sense of energy. My brain fog seems to clear somewhat and I can count on functioning reasonably well for about three to four hours. It feels like I've consumed a triple shot latte, but the effects arrive more gradually and taper more slowly than a post coffee crash.
It also does not seem to cause my blood sugar to drop either, as I have frequently noticed with caffeine. Sounds great, right? Unfortunately, modafinil also has its disadvantages. The energy created by this medication is not authentic energy - I only feel as though I have my old reserves back. If I don't monitor myself carefully, I will overstep my limits and pay for this with a three day crash and burn session.
Some people experience a kind of euphoria when taking this medication. It does have addictive properties similar to those of amphetamines, and is considered a schedule IV drug, meaning that is a controlled substance and must be prescribed and closely monitored by your physician.
Unfortunately for me, or maybe fortunately, depending on how you look at it, I don't seem to experience the euphoric effects. Modafinil is also extremely expensive. I am fortunate that my insurance covers most of the cost of this prescription. I have found that I get the best "bang for the buck" with this medication if I take it very infrequently. The effects are much less pronounced if I take it for several days in a row. My body seems click to see more become quickly acclimated to its use, so I only take it when I know that I need a serious boost.
There are other possible problems in using this medication. These were taken from the Provigil website: Although modafinil has not been shown to produce functional impairment, any drug affecting the CNS may alter judgment, thinking or motor skills. Patients should be cautioned about operating an automobile or other hazardous machinery until it is reasonably certain that PROVIGIL therapy Provigil For Autoimmune Fatigue not adversely affect their ability to engage in such activities.
Patients with a recent history of myocardial infarction or unstable angina should be treated with caution.
PROVIGIL tablets should not be used in patients with a history of left ventricular hypertrophy or in patients with mitral valve prolapse who have experienced the mitral valve prolapse syndrome when previously receiving CNS stimulants. There were also a greater proportion of patients on PROVIGIL requiring new or increased use of antihypertensive medications compared to patients on placebo.
For me, modafinil is one of several tools used in my management of autoimmune fatigue. It may be helpful for others as well, but only after careful assessment, prescription, and ongoing monitoring by your physician. I will have to ask my Rheumy if this is something I can try I need all the extra energy I can get. I take Nuvigil, which is the same I think. I was first diagnosed Provigil For Autoimmune Fatigue Chronic Fatigue Syndrome but then my joints started swelling along with the pain, so now it's Psoriatic Arthritis.
Modafinil is a psychostimulant drug approved by the FDA primarily for the treatment of sleep disorders such as narcolepsy, excessive daytime sleepiness and sleep apnea.
Several documented but not yet approved uses for modafinil have been described over the last 30 years, including alleviating fatigue in neurological and neurodegenerative disorders.
Provigil (Modafinil) - Oral
Recent evidence has suggested that modafinil may have an immunomodulatory effect. For general information, Learn About Clinical Studies.
Try the modernized ClinicalTrials. Learn more about the modernization effort. Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information. Search for terms. Save this study. Warning You have reached the maximum number of saved studies Fatigue Treatment Using Provigil The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Listing a study does not mean it has been evaluated by the U. Federal Government.Modafinil goes well beyond addressing fatigue. This medication is also commonly prescribed off label for chronic fatigue, ADHD, mood boosting. Official Title: Fatigue Treatment Using Provigil in Patients With Relapsing Remitting Multiple Sclerosis. Study Start Date: September
Read our disclaimer for details. Recruitment status was: Recruiting First Posted : September 22, Last Update Posted : February 17, Study Description.
To determine whether therapy with Modafinal Provigil is safe and effective Ftigue fatigue in MS Patients. Detailed Description:.
As fatigue is a subjective and non-specific symptom, and can easily be confused with either weakness or depressed mood, both common in MS, the following characteristics have been defined to better diagnose MS-associated Autoimmue MS-related fatigue generally occurs on a daily basis. It tends to worsen as the day progresses.
Reasonably Well: Provigil Use In Autoimmune Disease
It tends to be aggravated by heat and humidity. It is not directly correlated with either depression or the degree of physical impairment.
It may Fkr first thing in the morning even if the patient has had a restful full night's sleep. MedlinePlus related topics: Fatigue Multiple Sclerosis.
Drug Information available for: Modafinil. FDA Resources.
Modafinil acts on resident glial cells and infiltrating immune cells, negatively affecting both innate and adaptive immune responses in the. Although modafinil has not been shown to produce functional impairment, any drug affecting the CNS may alter judgment, thinking or motor skills.