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Prog Brain Res : — Ballon JS, Feifel D A systematic review of modafinil: potential clinical uses and mechanisms of action. J Clin Psychiatry 67 : — Effects of modafinil on cognitive and meta-cognitive performance.

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Sleep 26 : — Modafinil for excessive sleepiness associated with shift-work sleep disorder. N Eng J Med : — A double-blind, placebo-controlled trial of modafinil for cocaine dependence. Neuropsychopharmacology 30 : — Dagan Y, Doljansky JT Cognitive performance during sustained wakefulness: a low dose of caffeine is equally effective as modafinil in alleviating the nocturnal decline.

Chronobiol Int 23 : — Sexual dimorphism of the catechol-O-methyltransferase gene in narcolepsy is associated with response to modafinil. Pharmacogenomics J 2 : 65— Variations in extracellular monoamines in the prefrontal cortex and medial hypothalamus after modafinil administration: a microdialysis study Provigil Chemical Formula rats.

Lack of pre-synaptic dopaminergic involvement in modafinil activity in anaesthetized mice: in vivo voltammetry studies. Neuropharmacology 33 : — A prospective trial of modafinil as an adjunctive treatment of major depression. J Clin Psychopharmacol 24 : 87— Influence of modafinil on somatosensory input processing in the human brain-stem. Clin Neurophysiol : — Dequardo JR Modafinil-associated clozapine toxicity. Am J Psychiatry : — Evidence for co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex.

Mol Psychiatry 6 : — Alpha2-adrenoceptor mediated co-release of dopamine and noradrenaline from noradrenergic neurons in the cerebral cortex. J Neurochem 88 : — Mirtazapine-induced corelease of dopamine and noradrenaline from noradrenergic neurons in the medial prefrontal and occipital cortex. Eur J Pharmacol : — Stimulation of the locus coeruleus elicits noradrenaline and dopamine release in the medial prefrontal and parietal cortex.

J Neurochem 92 : — Co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex induced by clozapine, the prototype atypical antipsychotic. Psychopharmacology : 79— Dissociation in prefrontal cortex of affective and attentional shifts. Nature : 69— Pharmacodynamic effects on alertness of single doses of armodafinil in healthy subjects during a nocturnal period of acute sleep loss.

Curr Med Res Opin 22 : — Durstewitz D, Seamans JK The computational role of dopamine D1 receptors in Provigil Chemical Formula memory. Neural Netw 15 : — Article PubMed Google Scholar. A possibe alpha-adrenergic mechanism for drug CRL -induced hyperactivity. Eur J Pharmacol 59 : — Central alpha 1-adrenergic stimulation in relation to the behaviour stimulating Provigil Chemical Formula of modafinil; studies with experimental animals. Eur J Pharmacol : 49— Differential effects of modafinil and methylphenidate on stop-signal reaction time task performance in the rat, and interactions with the dopamine receptor antagonist cis-flupenthixol.

Modafinil induces wakefulness without intensifying motor activity or subsequent rebound hypersomnolence in the rat. J Pharmacol Exp Ther : — Functional magnetic resonance imaging neuroactivation studies in normal subjects and subjects with the narcoleptic syndrome. Actions of modafinil. J Sleep Res 8 : 85— Brain regional substrates for the actions of the novel wake-promoting agent modafinil in the rat: comparison with amphetamine.

Neuroscience 87 : — Differential patterns of regional c-Fos induction in the rat brain by amphetamine and the novel wakefulness-promoting agent modafinil. Neurosci Lett : 95— Modafinil and unconstrained motor activity in schizophrenia: double-blind crossover placebo-controlled trial. Br J Psychiatry : — A multicenter, placebo-controlled study of modafinil augmentation in partial responders to selective serotonin reuptake inhibitors with persistent fatigue and sleepiness.

J Clin Psychiatry 66 : 85— The antinarcoleptic drug modafinil increases glutamate release in thalamic areas and hippocampus.

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Synapse New York, NY 55 : — Amplification of cortical serotonin release: a further neurochemical action of the vigilance-promoting drug modafinil. Neuropharmacology 39 : — Differential enhancement of dialysate serotonin levels in distinct brain regions of the awake rat by modafinil: possible relevance for wakefulness and depression. J Neurosci Res 68 : — Modafinil does not affect serotonin efflux from rat frontal cortex synaptosomes: comparison with known serotonergic drugs.

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Comparison with amphetamine. Exp Brain Res : — Evidence for a protective action of the vigilance promoting drug modafinil on the MPTP-induced degeneration of the nigrostriatal dopamine neurons in the black mouse: an immunocytochemical and biochemical analysis.

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Nat Rev 4 : — The efficacy and safety of armodafinil as treatment for adults with excessive sleepiness associated with narcolepsy. Modafinil attenuates disruptions in cognitive performance during simulated night-shift work. Neuropsychopharmacology 31 : — Steady-state pharmacokinetics and tolerability of modafinil given alone or in combination with methylphenidate in healthy volunteers. J Clin Pharmacol 41 : — Steady-state pharmacokinetics and tolerability of modafinil administered alone or in combination with dextroamphetamine in healthy volunteers.

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Modafinil increases histamine release in the Provigil Chemical Formula hypothalamus of rats. Jasinski DR An evaluation of the abuse potential of modafinil using methylphenidate as a reference.

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J Comp Neurol : — Alpha-2 adrenergic modulation of prefrontal cortical neuronal activity related to spatial working memory in monkeys. Neuropsychopharmacology 21 : — J Provigil Chemical Formula Res 9 : 89— Potential brain neuronal targets for amphetamine- methylphenidate- and modafinil-induced wakefulness, evidenced by c-fos immunocytochemistry in the cat.

Role of catecholamines in the modafinil and amphetamine induced wakefulness, a comparative pharmacological study in the cat. Modafinil reduces excessive somnolence and enhances mood in patients with myotonic dystrophy. Neurology 59 : — Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. Modafinil and cocaine interactions. Am J Drug Alcohol Abuse 32 : — Dopamine decreases the calcium-activated afterhyperpolarization in hippocampal CA1 pyramidal cells.

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Pharmacol Biochem Behav 86 : — Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. Effects of modafinil on working memory processes in humans. D1 receptor in interneurons of macaque prefrontal cortex: distribution and subcellular localization.

J Neurosci 18 : — Modafinil enhances extracellular levels of dopamine in the nucleus accumbens and increases wakefulness in rats. Behav Brain Res : — Modafinil: preclinical, clinical, and post-marketing surveillance—a review of abuse liability issues.

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Oskooilar N A case of premature ventricular contractions with modafinil. Central histaminergic system and cognition. Neurosci Biobehav Rev 24 : — Effects of the vigilance promoting drug modafinil on the synthesis of GABA and glutamate in slices of rat hypothalamus. Modafinil-induced modulation of working memory and plasma corticosterone in chronically-stressed mice. Pharmacol Biochem Behav 83 : 1—8.

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Hum Psychopharmacol 18 : — Does modafinil enhance cognitive performance in young volunteers who are not sleep-deprived? J Clin Psychopharmacol 25 : — Ranjan S, Chandra PS Modafinil-induced irritability and aggression? A report of 2 bipolar patients. Richer F, Beatty J Contrasting effects of response uncertainty on the task-evoked pupillary response and reaction time. Psychophysiology 24 : — In vitro inhibition and induction of human hepatic cytochrome P enzymes by modafinil.

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J Neurol : — Low-resolution brain electromagnetic tomography LORETA identifies brain regions linked to psychometric performance under modafinil in narcolepsy.

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Sawaguchi T Attenuation of delay-period activity of monkey prefrontal neurons by an alpha2-adrenergic antagonist during an oculomotor delayed-response task. J Neurophysiol 80 : — D1 dopamine receptors in prefrontal cortex: involvement in working memory. Science : — The role of D1-dopamine receptor in working memory: local injections of dopamine antagonists into the prefrontal cortex of rhesus monkeys performing an oculomotor Chemlcal task.

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J Child Adolesc Psychopharmacol 10 : — Modafinil augmentation of SSRI therapy in patients with major depressive disorder and excessive sleepiness and fatigue: a week, open-label, extension study. CNS Spectrums 11 : 93— Thomas RJ, Kwong K Modafinil activates cortical and subcortical sites in the sleep-deprived state. Sleep 29 : — Effects of modafinil-induced wakefulness on glutamine synthetase regulation in the rat brain.

Brain Res Mol Brain Res 26 : — Proviigil properties of modafinil without paradoxical sleep rebound: comparative study with amphetamine in the rat. Neurosci Lett : 43— Detection of modafinil in human urine by gas chromatography-mass spectrometry. J Pharm Biomed Anal 39 : — Biol Psychiatry 55 : — Modafinil improves Cheemical and attentional set shifting in patients with chronic schizophrenia.

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