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Provigil Tab 200mg

Provigil Performance Enhancement - Provigil Abc Article

Posted by Gardagrel on 2022-06-21

In addition, several intentional acute overdoses occurred; the two largest being mg and mg taken by two subjects participating in foreign depression studies. None of these study subjects experienced any unexpected or life-threatening effects. Adverse reactions that were reported at these doses included excitation or agitation, insomnia, and slight or moderate elevations in hemodynamic parameters.

Other observed high-dose effects in clinical studies have included anxiety, irritability, aggressiveness, confusion, nervousness, tremor, palpitations, sleep disturbances, nausea, diarrhea, Provigil Tab 200mg decreased prothrombin time. From postmarketing experience, there have been reports of fatal Provigil Tab 200mg involving modafinil alone or in combination with other drugs.

Symptoms most often accompanying PROVIGIL overdose, alone or in combination with other drugs have included insomnia; central nervous system symptoms such as restlessness, disorientation, confusion, agitation, anxiety, excitation, and hallucination; digestive changes such as nausea and diarrhea; and cardiovascular changes such Provugil tachycardia, bradycardia, hypertension, and chest 200ng.

The child remained stable. The symptoms associated with overdose in children were similar to Tag observed in adults. Such 200jg should be managed with primarily supportive care, including cardiovascular monitoring. Modafinil is a racemic compound. Modafinil is a white to off-white, crystalline powder that is practically insoluble in water and cyclohexane. It is sparingly to slightly soluble in methanol and acetone.

Provigil 200 mg tablet

PROVIGIL tablets contain mg or mg of modafinil and the following inactive ingredients: croscarmellose sodium, lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone, and pregelatinized Prpvigil. The mechanism s through which modafinil promotes wakefulness is unknown. Modafinil has wake-promoting actions similar to sympathomimetic agents including amphetamine and methylphenidate, although the pharmacologic profile is not identical to that of the sympathomimetic amines.

Modafinil is not a direct- or indirect-acting dopamine receptor agonist. However, in vitro, modafinil binds to the dopamine transporter and inhibits dopamine reuptake.

DailyMed - PROVIGIL- modafinil tablet

This activity has been associated in vivo with increased extracellular dopamine levels in some brain regions of animals. In genetically engineered mice lacking the dopamine transporter DATmodafinil lacked wake-promoting activity, suggesting that this activity was DAT-dependent. However, the wake-promoting effects of modafinil, unlike those of amphetamine, were not antagonized by the dopamine receptor antagonist haloperidol in rats.

In addition, alpha-methyl-p-tyrosine, a dopamine synthesis inhibitor, blocks the action of amphetamine, but does not block locomotor activity induced by modafinil. In the cat, equal wakefulness-promoting doses of methylphenidate and Provigil Tab 200mg increased neuronal activation throughout the brain. Modafinil at an equivalent wakefulness-promoting dose selectively and prominently increased neuronal activation in more discrete regions of the brain.

The relationship of this finding in cats to the effects of modafinil in humans is unknown. In addition to its wake-promoting effects and ability to increase locomotor activity in animals, modafinil produces psychoactive and euphoric effects, alterations in mood, perception, thinking, and feelings typical of other CNS stimulants in humans.

Modafinil has reinforcing properties, as evidenced by its self-administration in monkeys previously trained to self-administer cocaine; modafinil was also partially discriminated as stimulant-like. The optical enantiomers of modafinil have Provigil Tab 200mg pharmacological actions in animals.

Provigil mg tablet | Kaiser Permanente

Two major metabolites of modafinil, modafinil acid and modafinil sulfone, do not appear to contribute to the CNS-activating properties of modafinil. Modafinil is a racemic compound, whose enantiomers have different pharmacokinetics e.

The enantiomers do not interconvert. At steady state, total exposure to R-modafinil is approximately three times that for S-modafinil. The effective elimination half-life of modafinil after multiple doses is about 15 hours. Apparent steady states of total modafinil and R-modafinil are reached after days of dosing. Food has no effect on overall PROVIGIL bioavailability; however, time to reach peak concentration t max may be delayed by approximately one hour if taken with food.

Urine alkalinization has no effect on the elimination of modafinil. Metabolism occurs through hydrolytic deamidation, S-oxidation, aromatic ring Provigil Tab 200mg, and glucuronide conjugation.

The largest fraction of the drug in urine was modafinil acid, but at least six other metabolites were present in lower concentrations.

Only two metabolites reach appreciable concentrations in plasma, i. In preclinical models, modafinil acid, modafinil sulfone, 2-[ diphenylmethyl sulfonyl]acetic acid and 4-hydroxy modafinil, were inactive Provigil Tab 200mg did not appear to mediate the arousal effects of modafinil. In adults, decreases in trough levels of modafinil have sometimes been observed after multiple weeks of dosing, suggesting auto-induction, but the magnitude of the decreases and the inconsistency of their occurrence suggest that their clinical significance is minimal.

Significant accumulation of modafinil sulfone has been observed after multiple doses due to its long elimination half-life of 40 hours. Due to potential effects from the multiple concomitant medications with which most of the patients were being treated, the apparent difference in modafinil pharmacokinetics may not be attributable solely to the effects of aging.

However, the results suggest that the clearance of modafinil may be reduced in the elderly [see Dosage and Administration 2. Provigil Tab 200mg pharmacokinetics and metabolism of modafinil were examined in patients with cirrhosis of the liver 6 men and 3 women.

Clinically 8 of 9 patients were icteric and all had ascites. In vitro data also demonstrated that modafinil produced an apparent concentration-related suppression of expression of CYP2C9 activity. Other CYP activities did not appear to be affected by modafinil. The existence of Provigil Tab 200mg pathways for modafinil metabolism, as well as the Provigil Tab 200mg that a non-CYP-related pathway is the most rapid in metabolizing modafinil, suggest that there is a low probability of substantive effects on the overall pharmacokinetic profile of PROVIGIL due to CYP inhibition by concomitant medications.

There was no evidence of tumorigenesis associated with modafinil administration in these studies. However, the mouse study was inadequate because the high dose was not a maximum tolerated dose MTD. Modafinil was negative in a series of in vitro i.

The criteria for narcolepsy include either: 1 recurrent daytime naps or lapses into sleep that occur almost daily for at least three months, plus sudden bilateral loss of postural muscle tone in association with intense emotion cataplexy ; or 2 a complaint of excessive sleepiness or sudden muscle weakness with associated features: sleep paralysis, hypnagogic hallucinations, automatic behaviors, disrupted major sleep episode; and polysomnography demonstrating one of the following: sleep latency less than 10 minutes or rapid eye movement REM sleep latency less than 20 minutes.

For entry into these studies, all patients were required to have objectively documented excessive daytime sleepiness, via a Multiple Sleep Latency Test MSLT with two or more sleep onset Provigil Tab 200mg periods and the absence of any other clinically significant active medical or psychiatric disorder.

For each test session, the subject was told to lie quietly and attempt to sleep. Each test session was terminated after 20 minutes if no sleep occurred or 15 minutes after sleep onset. For a successful trial, both measures had to show statistically significant improvement. The MWT measures latency in minutes to sleep onset averaged over 4 test sessions at 2 hour intervals following nocturnal polysomnography. For each test session, the subject was asked to attempt to remain awake without using extraordinary measures.

Each test Provigil Tab 200mg was terminated after 20 minutes if no sleep occurred or 10 minutes after sleep onset. Patients were rated by evaluators who had no access to Provigil Tab 200mg data about the patients other than a measure of their baseline severity. Evaluators were not given any specific guidance about the criteria they were to apply when rating patients.

Both studies demonstrated improvement in objective and subjective measures of excessive daytime Provigil Tab 200mg for both the mg and mg doses compared to see more. The criteria include either: 1 excessive sleepiness or insomnia, plus frequent episodes of impaired breathing during sleep, and associated features such as loud snoring, morning headaches Provigil Tab 200mg dry mouth upon awakening; or 2 excessive sleepiness or insomnia and polysomnography demonstrating one of the following: more than five obstructive apneas, each greater than Provigil Tab 200mg seconds in duration, per hour of sleep and one or more of the following: frequent arousals from sleep associated with the apneas, bradytachycardia, and arterial oxygen desaturation in association with the apneas.

CPAP use continued throughout the study. The primary measure of effectiveness was the change from baseline on the ESS at final visit. At week 4, the ESS was reduced by 4. All patients met the criteria for chronic SWD. The criteria include: 1 either, a a primary complaint of excessive sleepiness or insomnia which is temporally associated with a work period usually night work that occurs during the habitual sleep phase, or b polysomnography and the MSLT demonstrate loss of a normal sleep-wake pattern i.

It should be Рулит Provigil Results зачет that not all patients with a complaint of sleepiness who are also engaged in shift work meet the criteria for the diagnosis of SWD.

In the clinical trial, only patients who were symptomatic for at least 3 months were enrolled. Advise patients to stop taking PROVIGIL and to notify their physician right away Provigil Tab 200mg they develop a rash, hives, mouth sores, blisters, peeling skin, trouble swallowing Provigil Tab 200mg breathing, or a related allergic phenomenon.

Advise patients not to alter their previous behavior with regard to potentially dangerous activities e. Inform patients that it may be critical that they continue to take their previously prescribed treatments e. Advise patients to stop taking PROVIGIL and contact their physician right away if they experience chest pain, rash, depression, anxiety, or signs of psychosis or mania. Advise patients to notify their physician if they become pregnant or intend to become pregnant during therapy.

Caution patients regarding the potential increased risk of pregnancy when using steroidal contraceptives including depot or implantable contraceptives with PROVIGIL and for one month after discontinuation of therapy. There may be new information. This information does not take the place of talking with your doctor about your medical condition or treatment.

PROVIGIL may cause serious side effects including a serious rash or a serious allergic reaction that may affect parts of your body such as your liver or blood cells. Any of these may need to be treated Of Provigil Effects Generic Side a hospital and Provigil Tab 200mg be life-threatening.

If you have a severe rash with PROVIGIL, stopping the medicine may not keep the rash from becoming life-threatening or causing you to be permanently disabled or disfigured. PROVIGIL is a prescription medicine used to improve wakefulness in adults who are very sleepy due to one of the following diagnosed sleep disorders:. Follow your doctor's advice about good sleep habits and using other treatments.

Tell your doctor if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs. Tell your doctor about all of your medical conditions including, if you:. Tell your doctor about all the medicines you takeincluding prescription and over-the-counter medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them and show it to your doctor and pharmacist when you get a new medicine.

For more information, ask your doctor or pharmacist. Call your doctor Provigil Tab 200mg medical advice about side effects. Medicines are sometimes prescribed for purposes other Provigil Tab 200mg those listed in a Medication Guide.

It may harm them and it is against the law. If you would like more information, talk with your doctor. For more information, call Inactive Ingredients: lactose monohydrate, microcrystalline cellulose, pregelatinized starch, croscarmellose sodium, povidone, and magnesium stearate. Rx only teva. DailyMed will deliver notification of updates and additions to Drug Label information currently shown on this site through its RSS feed.

DailyMed will deliver this notification to your desktop, Web browser, or e-mail depending on the RSS Reader you select to use. Due to inconsistencies between the drug labels on DailyMed and the pill images provided by RxImagewe no longer display the RxImage pill images associated with drug labels. We anticipate reposting the images once we are able identify and filter out images that do not match the information provided in the drug labels.

View Package Photos. Drug Label Info. NDC National Drug Code - Each drug product is assigned this unique number which can be found on the drug's outer packaging. Approval: The following serious adverse reactions are described elsewhere in the labeling: Serious Rash, including Stevens-Johnson Syndrome [see Warnings and Precautions 5. Table 1.

Cardiovascular: Stroke Hematologic: agranulocytosis Psychiatric disorders: psychomotor hyperactivity. The chemical structure is:. Gender The pharmacokinetics of modafinil are not affected by gender.

Race The influence of race on the pharmacokinetics of modafinil has not been studied. Hepatic Impairment The pharmacokinetics and metabolism of modafinil were examined in patients with cirrhosis of the liver 6 men and 3 women.

Therefore, the blood levels and effectiveness of drugs that are substrates for CYP3A enzymes e. There was no apparent change in the elimination rate of ethinyl estradiol. This medication does not cure these sleep disorders and may not get Provigil Tab 200mg of all your sleepiness. Modafinil does not take the place of getting enough sleep. It should not be used to treat tiredness or hold off sleep in people who do not have a sleep disorder.

It is not known how modafinil works to keep you awake. Read the Medication Guide provided by your pharmacist before you start using modafinil and each time you get a refill. If you have any questions, ask your doctor or pharmacist. For narcolepsy, take this medication by mouth with or without food as directed by your doctor, usually once daily in the morning. Or, if your doctor directs you to, the total daily dose of modafinil may be divided into a morning dose and a noon dose.

For obstructive sleep apnea, take this medication by mouth with or without food as directed by your doctor, usually once daily in the morning.

Continue your other treatment such as the CPAP machine, mouth device unless your doctor tells you to stop. If you are using modafinil for shift work sleep disorder, take it by mouth with or without food as directed by your doctor, usually once a day 1 hour before you start your work shift.

The dosage is based on your medical condition and response to treatment. Take this medication regularly to get the most benefit from it. If you suddenly stop using this medication, you may have withdrawal symptoms such as shaking, sweating, chills, nausea, vomiting, confusion.

To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used modafinil for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal. Provigil Tab 200mg this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well. Though it helps many people, this medication may sometimes cause addiction.

Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details. Headache, nausea, nervousness, dizziness, or difficulty sleeping may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact Provigil Tab 200mg doctor or pharmacist. Call your doctor for medical advice about side effects. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at Before taking modafinil, tell your doctor or pharmacist if you are allergic to it; or to armodafinil; or if you have any other allergies.

This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of:.

Sleep disorders may reduce your ability to react quickly. Though modafinil helps keep you awake, you still may not be able to safely do things that require quick reactions such as driving. This drug may also make you dizzy. Alcohol or marijuana cannabis can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely.

Avoid alcoholic beverages. Talk to your doctor Provgiil you are using marijuana cannabis. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products.

Tell your doctor if you are pregnant or plan to become pregnant.

PROVIGIL tablets contain mg or mg of modafinil and the following inactive ingredients: croscarmellose sodium, lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone, and pregelatinized starch. PROVIGIL tablets contain mg or mg of modafinil and the following inactive ingredients: lactose, microcrystalline cellulose, pregelatinized starch, croscarmellose sodium, povidone, and magnesium stearate.

You should Provvigil become pregnant while using modafinil. Modafinil may harm an unborn baby. Ask about reliable forms of non-hormonal birth control while using this medication and for 2 months after stopping treatment. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.

Drug interactions may change how your medications work or increase Provigil Tab 200mg risk for serious side effects. This document does not contain all possible drug interactions. Do not start, stop, or change the dosage of any medicines without your doctor's approval. This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy.

Modafinil is indicated in adults for the treatment of excessive sleepiness associated with narcolepsy with or without cataplexy. Excessive sleepiness is defined. PROVIGIL tablets contain mg or mg of modafinil and the following inactive ingredients: croscarmellose sodium, lactose monohydrate.

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