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Training lasted for 7 consecutive days, during which the dividing wall was solid and Proivgil access to only one side of the chamber at a time. On each day, mice received an injection of saline and were immediately placed into the Saline side of the chamber.

After 15 min, they were removed from the chamber, given a group-appropriate drug injection, and placed into the Drug side. After an additional 15 min, they were returned to their home cage. Schematic of procedure for Experiment 1.

A On Days 1—7, mice first received an injection of saline and were placed into the Saline Side of the chamber for 15 min. This data is depicted in Fig. B During conditioned place preference testing a small hole between the two sides of the chamber allowed Snort Provigil Erowid access to either side of the chamber.

On Day 10, all mice received an injection of saline and were placed into the chamber for 15 min. C In order to test the context and drug specificity of EErowid, all mice received modafinil and saline on each of the Saline and Drug Sides. On Day 13, mice first received an injection of saline and were placed into the Saline Side for 15 min. Snotr after, mice received an injection Snorrt modafinil 0.

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Snort Provigil Erowid, on Day 14, mice first received an injection of saline and were placed into the Drug Side for 15 min. For Experiment 2, animals were then trained identically to part A above with either low dose modafinil LoMod Erowkd saline. CPP testing occurred 3 days after the final day of training. The solid wall separating the two sides of the chamber was replaced with an identical insert with a small Eroiwd allowing passage between the two sides.

All groups received the same drug treatments during testing. The testing paradigm is shown in Fig. On Day 10, mice were given a standard place preference test: following an injection of saline, they were placed into the small hole Snott the two sides of the chamber and allowed to explore both sides for 15 min. Time spent in each side was measured by computer. Locomotor sensitization is specific to the context in which the drug is received [ 34 ]. Thus, sensitization can be measured as the difference between a challenge in the drug side and a challenge in the saline side [ 38 Erwoid.

Following CPP tests, the specificity of sensitization was tested Snort Provigil Erowid administering a challenge dose of modafinil 0. This low dose of modafinil was chosen as a clinically relevant dose and because we have found it Snort Provigil Erowid as a cognitive enhancer selectively enhancing hippocampus-dependent click fear conditioning without producing locomotor activity [ 4 ].

During these tests the dividing wall was solid allowing access to only one side of the chamber at a time. On Day 13, all mice from all groups received saline in the side previously paired with saline, followed 3 h later by modafinil in the side previously paired with drug. On Day 14, mice Snoft saline in the Provigjl side, followed Snort Provigil Erowid h later by modafinil in the saline-paired side.

Each test lasted 15 min, and locomotor activity was scored. Low dose modafinil Sigma—Aldrich, St. Saline control animals received vehicle of 0. Eight mice were tested concurrently, in individual chambers housed in a windowless room.

Chambers cm wide, cm high, cm deep, Med Associates, St. Albans, VT consisted of two distinct sides Sjort by a wall with a removable hole.

The two sides differed in smell, texture, and visual stimuli. During training, the hole in the dividing wall was closed which allowed access to only one side at a time.

Animals were tracked using infrared beams and Activity Monitor software Med Associates and locomotor distance traveled was scored. Light was provided from two Watt bulbs distant from the chambers and background noise dBA was provided by HEPA air cleaners and an iPod speaker playing white noise.

Training was as in Experiment 1, but a low dose of modafinil LoMod, 0. This low dose is closer to the dose given to humans without respect to species differences and enhances Pavlovian fear conditioning in mice [ 4 ].

Two groups were examined: mice were randomly assigned to receive either modafinil 0. Training lasted for 7 consecutive days, during which the hole in the dividing wall was closed and allowed access to only one side of the chamber at a time.

As with Experiment 1, CPP testing occurred 3 days after the final day of training. Mice were given a standard place preference test: following an injection of saline, they were placed into the small hole between the two sides of the chamber and allowed to explore both sides for 15 min. As with Experiment 1, the specificity of sensitization was tested by administering a challenge dose of Snort Provigil Erowid 0.

Locomotor sensitization was assessed over the 7 days of training. Locomotor activity for all groups is depicted across training as time-course data and averages Fig. In order to establish the presence of sensitization, two criteria were required: 1 the Day 7 chronic response had to be higher than the Day 1 acute response, and 2 the Day 7 response Snort Provigil Erowid to be higher than the Day 7 response in Saline controls.

These requirements avoid the confound of habituation occurring only in the control group leading to a lack of habituation being mistaken for sensitization [ Snort Provigil Erowid ]. In order to further examine sensitization, we subtracted locomotor activity on Day 1 from Day 7, shown as a time course in Fig. Visual inspection of Fig. In order to explore this further, we examined the difference from zero for the Day 7 minus Day 1 subtraction on a minute-by-minute basis. Cocaine mice exhibited sensitization across most minutes min 1—2, n.

Even when considered on a minute-by-minute basis there was no evidence for sensitization in the Modafinil group, only evidence for habituation in the Saline control group. Induction of sensitization.

Modafinil - PsychonautWiki

A Time course of drug action on Day 1 of training. Modafinil alone failed to induce substantial locomotion. B Time course of drug action on Day 7 of training. All three drug groups showed an increased response over the saline control group. C Time course of locomotor sensitization.

The difference in response from Day 1 to 7 is shown. Modafinil mice did not differ from control mice. D Locomotor activity after saline treatment, by day.

No group differences were observed. E Average locomotor activity after drug treatment, by day. F Difference in locomotor activity of drug training trials between Day 1 and Day 7. All animals received a place preference test after receiving a saline injection Fig.

Data is depicted as the difference in time spent in Snort Provigil Erowid drug- and saline-paired sides of the chamber.

Overall, these data show that cocaine and high dose modafinil induce a strong and significant place preference; no additional place preference is Snort Provigil Erowid if cocaine and high dose modafinil are combined i.

Place preference and cross-sensitization testing. A After a saline injection, all three drug groups spent significantly more time in the drug-paired side of the chamber.

An Experience with Provigil (Modafinil). 'My Nose Candy' by the Marina stoner. I was prescribed Provigil for my constant drowsiness that I seemed to have been succumbing to during and after my time on Prozac.

The difference in time spent in drug-paired side and saline-paired side is shown. B Locomotor activity Snort Provigil Erowid the drug-paired side minus the saline paired side after an injection of a challenge dose of modafinil 0. Thus, the sensitization observed in these groups cross-sensitized to modafinil administration.

C Locomotor activity in Probigil drug-paired side minus the saline paired side after an injection of saline. No significant group effects were found. To examine context-specific sensitization we conducted modafinil and saline tests with the animals restricted to one side of the chamber Fig. We administered modafinil in both the drug-paired and unpaired sides of the chamber.

We subtracted the unpaired side from the drug side to obtain a measure of go here specific sensitization to modafinil [ 38 ]. Group differences were found Fig. Animals that had received only Snnort during training, on the other hand, did not exhibit sensitization in the drug-paired context. These effects were not due to conditioned hyperactivity as no group differences Snort Provigil Erowid found when saline was administered on both sides Fig.

This is consistent with prior work showing that a conditioned locomotor response is not readily observed within the CPP paradigm [ 38 ]. Locomotor sensitization of low dose modafinil LoMod was Erosid over the 7 days of training Fig. This data is depicted minute-by-minute Fig. When difference scores were computed to estimate this reduction Fig. Low dose modafinil does not induce sensitization or place preference.

Provigi Time course of drug action on Day 1 left and Day 7 right of training. Low-dose Modafinil LoMod and Saline groups did not differ. B Average locomotor activity after saline treatment left and drug treatment rightby day.

No group differences were found. C Difference in locomotor activity of drug training trials between Day 1 and Day 7 shown as minute-by-minute left or averages right. Both groups showed equivalent decreases from Day 1 to Day 7.

D Left Snort Provigil Erowid, conditioned place preference test displayed as the difference in time spent in the Drug and Saline sides. Both groups of mice Provjgil a roughly equal amount of time in each side of the chamber. Middlelocomotor activity in the drug-paired side minus the saline paired side after an injection of a challenge dose of modafinil 0.

Neither the LoMod or Saline group showed higher locomotor activity in the drug paired side. Rightlocomotor activity in the drug-paired side minus the saline paired side after an injection of saline.

Neither group exhibited a significant place rEowid [ Fig. As with Experiment 1, we administered modafinil in both the drug-paired and unpaired sides of the chamber Erowie. We again subtracted the unpaired side from the drug side to obtain a measure of context specific sensitization to modafinil Proviggil 38 ]. We examined the interactions between modafinil and cocaine in the induction Eeowid locomotor sensitization and conditioned place preference.

These findings are discussed in turn below. It was Edowid, however, that modafinil and cocaine induced a similar level of place preference, since cocaine is considered to be much more reinforcing.

Nonetheless, our results should not be used to conclude that modafinil is equally as rewarding as cocaine because there are likely ceiling effects involved in the CPP paradigm. Moreover, CPP can indicate whether a drug is rewarding, but is not a sensitive measure of the degree of reward given that even natural reinforcers, such as sucrose, can induce CPP [ Provigip ].

Second, high dose modafinil induced little or no behavioral sensitization. Two previous studies have found modafinil induces some locomotor sensitization [ 2324 ]. It is unclear why sensitization occurred in Prrovigil other studies, but not in the current study. One difference between the studies is the time window examined. The current study examined only the first 15 min after i.

Paterson et al. It is possible that the time window rEowid was not sufficient to see locomotor sensitization. This appears unlikely, however, because modafinil was sufficient to observe sensitization in cocaine-trained animals within the min test. Furthermore, previous rodent studies have shown that peak locomotor activity occurs between Snoet and 40 min after administration [ 3340 ] however these studies only examined 20 min bins and thus it is unclear where Sbort true peak activity occurs.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found Proviil. The long-term safety and effectiveness of modafinil as a drug of regular usage have not been determined.

Anecdotal reports from people who have tried modafinil suggest that there do not seem to be any negative health Snort Provigil Erowid attributed to simply trying this substance at low to moderate doses by itself or using it sparingly but nothing can be completely guaranteed. It is worth noting that as this compound is a commonly prescribed pharmaceutical, it is considerably less likely to have unpredictable adverse health effects than the typical research chemical. Nevertheless, it is strongly recommended Etowid one use harm reduction practices if using this substance.

No life-threatening effects have taken place in clinical trials involving the Provlgil of mg to mg of modafinil per day for 7 to 21 consecutive days. Intentional acute overdoses of mg and mg in two adult subjects and an accidental ingestion of mg by a three-year-old child did not result in any life-threatening effects or death.

"Snorting the Gel: An Experience with Fentanyl (exp)". .serp-item__passage{color:#} COPYRIGHTS: All reports are copyright Erowid and you agree not to download or analyze the report data without contacting Erowid Center and. provigil erowid vault; snorting provigil mg  Avis Provigil Erowid. provides accurate and independent information on more than 24, prescription drugs, over-the-counter medicines and natural products.

The chronic use of modafinil can be considered as not addictive with a Snort Provigil Erowid potential for abuse. It does not seem to be capable of causing Snort Provigil Erowid dependence among Prpvigil users. Tolerance to many of the effects of modafinil develops with prolonged and Online Mexico use.

This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline in the absence of further consumption. Modafinil may present a cross-tolerance with all benzhydryl nootropicsmeaning that after the consumption of modafinil, all related eugeroic compounds such as armodafinil and adrafinil will display a reduced Snort Provigil Erowid.

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions although it is not guaranteed to include all of them. Always conduct independent Erlwid e. GoogleDuckDuckGoPubMed to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Although Modafinil may cause nausea and acid reflex, it should not be taken together with omeprazole which Provigjl a CYP2Csubstrate. Modafinil is legally approved for medical purposes worldwide. However, it is illegal to sell and possess in most countries without a prescription.

From PsychonautWiki. Summary sheet: Modafinil Modafinil. Physical effects. Cognitive effects. When he joined the circuit, in the late nineties, he was already a millionaire: a twenty-something tech guy who had started off writing software, helped found an Internet portal called go2net, and cashed in at the right moment. He was cerebral and, at times, brusque.

His nickname was Dot Com. On the international poker-tournament scene—where the male players tend to be either Edowid schlumpy Erosid sharply dressed in Snort Provigil Erowid manner of a Vegas hotel manager—Phillips cultivated a geeky New Wave style. He wore vintage shirts in wild geometric patterns; his hair was dyed orange or silver one week, shaved off the next. Most unusual of all, Phillips talked freely about taking prescription drugs—Adderall and, especially, Provigil—in order to play better cards.

He first took up the game inwhen he was in college, at U. San Diego. Phillips soon felt that he had mastered the strategic aspects of poker. The key variable was execution. At tournaments, he needed to be able to stay focussed for fourteen hours at a stretch, often for several days, but he found it difficult to do so.

Ina doctor gave him a diagnosis of A. Adderall not only helped him concentrate; it also helped him resist the impulse to keep playing losing hands out of boredom. InPhillips asked his doctor to give him a prescription Provigol Provigil, which he added to his Adderall regimen. Last summer, I visited Phillips in the high-desert resort town of Bend, Oregon, where he lives with his wife, Kathleen, and their two daughters, Ivy and Ruby.

Phillips, who is now thirty-six, seemed a bit out of place in Bend, where people spend a lot of time skiing and river rafting.

Among the friendly, faithfully recycling locals, he was making an effort to Snort Provigil Erowid his caustic side. In person, he was more obliging. Phillips wore shorts and flip-flops and his black T-shirt displayed an obscure programming joke.

He doubted it, but allowed that it could. Provigil feels like enhancement. He was good, Prrovigil not that good. With modafinil, I could continue for almost three hours. Cephalon, the Provigil manufacturer, has publicly read article the idea that the drug can be used as a smart pill.

Inresearchers at Cambridge University gave sixty healthy young male volunteers a battery of standard cognitive tests.

One group received modafinil; the other got a placebo. They also did better in recognizing repeated visual patterns and on a spatial-planning challenge known as the Tower of London task. He sighed when I suggested that adults, too, might feel coerced into using the drugs. But the fact is, the baseline competitive level is going to reorient around what these drugs make possible, and you can choose to compete or not. Inside, toys were strewn across the shag carpeting.

Phillips was waiting for his wife and daughters to Provigill home from the swimming pool, and, sitting in his huge, high-ceilinged living room, he looked a little bored. He told me that he had recently decided to apply to graduate school in computer programming. It was going to be hard—getting out all those applications, convincing graduate programs that he was serious about returning to school.

Brain Gain

Snort Provigil Erowid can be habit-forming. In a study published recently in the Journal of the American Medical Associationa group led by Nora Volkow, the director of the National Institute on Drug Abuse, scanned the brains of ten men after they Erowld been given a placebo, and also after they had been given a dose of modafinil.

The modafinil appeared to lead to Erowix increase in the brain chemical dopamine. On the Web Snrot Erowid, Snort Provigil Erowid people vividly, and anonymously, report their experiences with legal and illegal drugs, some modafinil users have described a dependency on the drug.

Eliminating foggy-headedness seems to be the goal of many users of neuroenhancers. She has been writing about neuroenhancers for several years from a perspective that is deeply fascinated and mildly critical, but basically in favor—with the important caveat that we need to know much more about how these Snort Provigil Erowid work.

I spoke with continue reading one afternoon at her research center, which is in a decidedly unfuturistic-looking Victorian house on Walnut Street, in Philadelphia. Farah, who is an energetic conversationalist, had bought canned espresso drinks for us.

Though she does not take neuroenhancers, she has found that her interest in them has renewed her romance with the next best thing: caffeine. Farah had just finished a paper in which she reviewed the evidence on prescription stimulants as neuroenhancers from forty laboratory studies involving healthy subjects. Most of the studies looked at one of three types of cognition: learning, working memory, and cognitive control.

A typical learning test asks subjects to memorize a list of paired words; an hour, a few days, or a week later, they are presented with the first words in the pairs and asked to come up with the second.

The studies on learning showed that neuroenhancers did improve retention. The benefits were more apparent in studies where subjects had been asked to remember information for several days or longer.

Imagine a cross-examination, in which a lawyer has to keep track of the answers a witness has given, and formulate new questions based on them. In one common test, subjects are shown a series of items—usually letters or numbers—and then presented with challenges: Was this number or letter in the series? Was this one?

The Snort Provigil Erowid category that the studies examined was cognitive control—how effectively you can Snort Provigil Erowid yourself in circumstances where the most natural response is the Provigil Pronounce one.

Drugs like Ritalin and Adderall work, Snort Provigil Erowid part, by elevating the amount of dopamine in the brain. Dopamine is something you want just enough rEowid too little, and you may not be as alert and motivated as you need to be; too much, and you may feel overstimulated. Neuroscientists have discovered that some people have a gene that leads the brain to break down dopamine faster, leaving less of it available; such people Eroiwd generally a little worse at certain cognitive tasks.

People with more available dopamine are generally somewhat better at the same tasks. It makes sense, then, that people with naturally low dopamine would benefit more from an artificial boost. Of course, learning, working memory, and cognitive Snort Provigil Erowid represent just a few aspects of thinking. Farah concluded that studies looking at other kinds of cognition—verbal fluency, for instance—were too few and too contradictory to tell us much. And the effects of neuroenhancers on some vital forms of intellectual activity, such as abstract thought and creativity, have barely been studied at all.

And there is some evidence that suggests that individuals who are better able to focus on one thing and filter out distractions tend to be less creative. Farah and Chatterjee recently Eorwid a preliminary study looking at the effect of one ten-milligram dose of Adderall on sixteen students doing standard laboratory tests of creative thinking. They did not find that this low dose had a detrimental effect, but both believe that this is only the beginning of the vetting that must be done.

Farah has also been considering the ethical complications resulting from the rise Provugil smart drugs. At many colleges, students have begun calling the off-label use of neuroenhancers a form of cheating.

As a semi-hypersomniac with a severe case of ADHD, I was prescribed Provigil in late June of It is being tested for off-label uses to. First, it is unclear how high dose modafinil interacts with cocaine in the formation of conditioned place preference and locomotor sensitization.

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