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That group showed fewer disturbances during the first recovery night than did the dextroamphetamine group. In particular, there were no REM sleep and slow-wave sleep deficits in the modafinil group. Moreover, the increase in REM sleep episodes observed with dextroamphetamine was not observed with modafinil.

The use of dextroamphetamine and modafinil appears to have beneficial effects on Provigil Dexedrine and meaningful performance of sleep-deprived individuals. Both drugs have been found to have positive effects on sleep-deprived individuals; however, they differ in their side effects. Modafinil appears to be a good to dextroamphetamine for elevating mood and cognitive effects of sleep loss during sustained operations, as well as having minimal side effects when taken in therapeutic doses.

It also appears to have low abuse potential, does not interfere with normal sleep cycles, and does not seem to produce tolerance.

Dexedrine (dextroamphetamine) is an effective medicine for treatment of ADHD, but often .serp-item__passage{color:#} Compare Provigil vs. Dexedrine. Head-to-head comparisons of medication uses, side effects, ratings, and more. ADVERTISEMENT. . Dexedrine vs Modafinil/Provigil. Jump to Latest Follow.  Fatigue from Dexedrine? No, it gives me energy and productivity. But I think I end up crashing after, and being out of commission for a day. That's why I'm curious to try a non-amphetamine.

Modafinil allows sleep to occur in patterns close to those of the placebo control group and decreases the need for a long sleep recovery to compensate for the sleep lost during sleep deprivation. Therefore, military operations can continue without the need to sustain pilots off duty.

Google Scholar. Google Preview. In: U. Awakening from sleep. Sleep Med Rev ; 6 : — Roehr TRoth T Sleep disorders: an overview. Clin Cornerstone ; 6 Suppl 1C : S6 — Novartis Found Symp ; : — Davis JM Central and peripheral factors in Provigi. J Sports Sci ; 13 Suppl : S49 — Hanneman SK Measuring circadian temperature rhythm. Biol Res Nurs ; 2 : — Clin Neuropharmacol ; 25 : — 4. Provigil Dexedrine J Neurobiological bases for the relation Provigil Dexedrine sleep and Provigiil.

Environ Health Perspect ; Suppl 4 : — 7. Aviat Space Environ Med ; 72 : — 6. Aviat Space Environ Med ; 55 : — J Sleep Res ; 14 : — Bassetti C Narcolepsy. Curr Treat Options Neurol ; 1 : Povigil 8. Brain regional substrates for the actions of Provigil Dexedrine novel wake-promoting agent modafinil in the rat: comparison with amphetamine.

Neuroscience ; 87 : — Encephale ; 17 : — Aviat Space Environ Med ; 62 : — 5. Sleep Res Online ; 1 : 49 — Vasagar J Nazis tested cocaine on camp inmates. The Guardian, November 19, Modafinil vs. Aviat Space Environ Med ; 75 : — 5. Aboul-Enein HY Amphetamine: a Provibil profile. Aviat Space Environ Med ; 74 : — Effects of modafinil on symptomatology of human narcolepsy.

Clin Neuropharmacol ; 16 : 46 — Caldwell JA Jr Effects of operationally effective doses of dextroamphetamine on heart rates and blood pressures of Army aviators. Provigil Dexedrine Med ; : — 8. Aviat Space Environ Med ; please click for source : 7 — Aviat Provigil Dexedrine Environ Med ; 66 : — 7.

Caldwell JACaldwell JL An in-flight investigation of the efficacy of dextroamphetamine for sustaining helicopter Provigil Dexedrine performance. Aviat Space Environ Med ; 68 : — Air Force tactical operations during Desert Shield and Storm. Aviat Space Environ Med ; 66 : — 3. Hum Psychopharmacol ; 19 : — Batejat DMLagarde DP Naps and modafinil as countermeasures for the effects of sleep deprivation on cognitive performance.

Aviat Space Environ Med ; 70 : — 8. Https:// HS Stimulant drugs and vigilance performance: a review.

Psychopharmacology Berl ; : 1 — Modafinil, d -amphetamine and placebo during 64 hours of sustained mental work: effects on mood, fatigue, cognitive performance and body temperature. J Sleep Res ; 4 : — Gold LHBalster RL Evaluation of the cocaine-like discriminative stimulus effects and reinforcing effects of modafinil. Psychopharmacology Berl ; : — Differential effects Provigil Dexedrine the new central adrenergic agonist modafinil and d -amphetamine on sleep and early morning behavior in elderlies.

Arzneimittelforschung ; 39 : — Interest of modafinil, a new psychostimulant, during a sixty-hour sleep deprivation experiment. Fundam Clin Pharmacol ; 9 : — Provogil. Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing DDexedrine.

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Article Navigation. Close mobile search navigation Article Navigation. Volume Dextroamphetamine versus Modafinil. Sleep Recovery. Psychostimulants and Military Operations. Uri EliyahuUri Eliyahu. Provigil Dexedrine Academic. Shai Berlin. Eran Hadad. Yuval Heled. Daniel S. Select Format Select format. Permissions Icon Permissions. Open in new tab. Naval Strike and Air Warfare Center. The role of sleep in sustaining individual and organizational effectiveness.

Google Scholar Crossref. Search ADS. Treatment of excessive daytime sleepiness in patients with Parkinson's disease with modafinil. CBS News. Survey of Israeli Air Force line commander support for fatigue prevention initiatives. Google Scholar PubMed. A review of Provigil Dexedrine physiological and performance changes associated with desynchronosis of biological rhythms. Performance and alertness effects of caffeine, dextroamphetamine, and modafinil during sleep deprivation.

Increased dopaminergic transmission mediates the wake-promoting effects of CNS stimulants. Effects of operationally effective doses of dextroamphetamine on heart rates and blood pressures of Army aviators. Efficacy of Dexedrine for maintaining aviator performance during 64 hours of sustained wakefulness: a simulator study. Sustaining helicopter pilot performance with Dexedrine during periods of sleep deprivation. An in-flight investigation of the efficacy of dextroamphetamine for sustaining helicopter pilot performance.

The use of amphetamines in U. Utility of dextroamphetamine for attenuating the impact of sleep deprivation in pilots. Naps and modafinil as countermeasures for the effects of sleep deprivation on cognitive performance.

Evaluation of the cocaine-like Provigil Dexedrine stimulus effects and reinforcing effects of modafinil. Issue Section:. Download all slides.

Psychostimulants and Military Operations | Military Medicine | Oxford Academic

Such strategies have also been effective for enhancing medication compliance Schmitz et al. To the extent that pill-taking burden Prpvigil this study, i. We opted to test this novel medication combination in a small number of subjects first to obtain evidence of efficacy and safety before designing a larger confirmatory study. Preliminary studies like this, however, have limitations, including unavoidable low statistical power and unreliable estimates.

To address this uncertainty, we included Bayesian probability distributions that are not affected by sample size and Provigil Dexedrine provide more quantitative conclusions regarding the probable Provigil Dexedrine read more effects Gurrin et al. Thus, we can Dexexrine with reasonable confidence that there is very Provigil Dexedrine evidential support for conducting a larger study of this medication combination for treatment of cocaine dependence.

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. We dedicate this work to David Herin, who died on February 19,after a determined battle with kidney cancer. Anderson, A. III, and Elkashef, A. Modafinil for the Profigil of cocaine dependence. Drug Alcohol Depend. Bayarri, M. The interplay of Dexecrine and frequentist analysis.

CrossRef Full Text. Businelle, M. Using vouchers to increase continuing care participation in veterans: does magnitude matter? Carroll, K. Efficacy of disulfiram and cognitive behavior therapy in cocaine-dependent outpatients: a randomized placebo-controlled trial.

Dexedrine (dextroamphetamine) Provigil (modafinil) is. Compare Dextroamphetamine vs Modafinil head-to-head with other drugs for uses, ratings, cost, side effects and interactions.

Psychiatry 61, — Dackis, C. A double-blind, placebo-controlled trial of modafinil for cocaine dependence. Neuropsychopharmacology 30, — Del Boca, F. Assessment of medication compliance in alcoholics through UV light detection of a riboflavin tracer. Elkashef, A. Biological markers of cocaine addiction: implications for medications development.

Ferraro, L. The vigilance promoting drug modafinil increases dopamine release in the rat nucleus accumbens via the involvement of a local GABAergic mechanism. Grabowski, J. Dextroamphetamine for cocaine-dependence treatment: a double-blind randomized clinical trial. Agonist-like or antagonist-like treatment for cocaine dependence with methadone for heroin Provigil Dexedrine two double-blind randomized clinical trials.

Neuropsychopharmacology 29, — Replacement medication for cocaine Provigil Dexedrine methylphenidate. Green, C. Provigil Dexedrine of heterogeneity in pharmacotherapy trials for drug dependence: a Bayesian approach.

Drug Alcohol Abuse 35, 95— Gurrin, L. Bayesian statistics in medical research: an intuitive Provigil Dexedrine to conventional data analysis. Herin, D. Agonist-like pharmacotherapy for stimulant dependence: preclinical, human laboratory, and clinical studies.

Longo, M. Randomized controlled trial of dexamphetamine maintenance for the treatment of methamphetamine dependence. Addiction— Madras, B.

Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. Margolin, A. A multicenter trial of bupropion for cocaine dependence in methadone-maintained patients. McLellan, A. The fifth edition of the addiction severity index. Abuse Treat. Moeller, F. Use of stimulants to treat cocaine and methamphetamine abuse. Psychiatry Rep. Mooney, M. Effects of oral methamphetamine on cocaine use: a randomized, double-blind, placebo-controlled trial.

Petrakis, I. Disulfiram treatment for cocaine dependence in methadone-maintained opioid addicts.

Addiction 95, — Poling, J. Six-month trial of bupropion with contingency management for cocaine dependence in Dexedrie methadone-maintained population. Psychiatry 63, — Rothman, R. Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin. Synapse 39, 32— Sayre, S. Provigil Dexedrine, J. Contingency management and levodopa-carbidopa for cocaine treatment: a comparison of three behavioral targets. Levodopa pharmacotherapy for cocaine dependence: choosing the optimal behavioral therapy platform.

Naltrexone and relapse prevention treatment for cocaine-dependent patients. Shearer, J. The principles of agonist pharmacotherapy for Provigil Dexedrine dependence. Drug Alcohol Rev. Pilot randomized double blind placebo-controlled study of dexamphetamine for cocaine dependence.

Addiction 98, — Spitzer, R. Classification of psychiatric disorders.

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JAMA—; author reply — Stout, R. Ensuring balanced distribution Dexedrinr Provigil Dexedrine factors in treatment outcome research. Alcohol Suppl. Pubmed Abstract Pubmed Full Text. Keywords: cocaine dependence, clinical trial, modafinil, d -amphetamine. Psychiatry 3 This is an open-access article distributed under the terms of the Creative Commons Attribution Licensewhich permits use, distribution and reproduction in other forums, provided the original Provigil Dexedrine and source are credited and subject to Provigl copyright notices concerning any third-party graphics etc.

Combination of modafinil and d -amphetamine for the treatment of cocaine dependence: a preliminary investigation Joy M. Green 2F.

Our objective was to compare the efficacy of the new wake-promoting drug modafinil to that of dextroamphetamine for the treatment of attention deficit. Provigil is a prescription medicine used to treat the symptoms of excessive sleepiness caused by obstructive sleep apnea, narcolepsy and shift work sleep.

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